New class of CNS medication employing a small molecule-controlled gene therapy. Development of a modified receptor that allows pharmaceutical targeting of specific neuronal populations.
CREATeTM
Chemogenetic Receptor Engineering for Advanced Therapeutics
01
CREATe-1
Various CNS diseases
02
CREATeTM technology
Original receptor:
expressed on neurons
when activated, affects (inhibits of excitates) the activity of neuron it is expressed on
Activated by its endogenous ligand (produced by another neuron)
May have some level of constitutive activity (without ligand)
Modified receptor (CREATeTM):
Expressed on specific neurons (defined by location and/or neurochemical attributes)
No constitutive activity
Does not bind its endogenous ligand (therefore not activated by it)
Activated by an exogenous drug (actuator)
Medical benefits:
Offers a safer alternative for some neurosurgery techniques (deep brain stimulation, lesion)
Effect can be fine-tuned (by actuator dose and timing), even temporarily or terminally eliminated (if no actuator is given)
Exact targeting better safety/efficacy profile then existing CNS therapies
01
CREATe-1
Various CNS diseases
02
CREATeTM technology
Original receptor:
expressed on neurons
when activated, affects (inhibits of excitates) the activity of neuron it is expressed on
Activated by its endogenous ligand (produced by another neuron)
May have some level of constitutive activity (without ligand)
Modified receptor (CREATeTM):
Expressed on specific neurons (defined by location and/or neurochemical attributes)
No constitutive activity
Does not bind its endogenous ligand (therefore not activated by it)
Activated by an exogenous drug (actuator)
Medical benefits:
Offers a safer alternative for some neurosurgery techniques (deep brain stimulation, lesion)
Effect can be fine-tuned (by actuator dose and timing), even temporarily or terminally eliminated (if no actuator is given)
Exact targeting better safety/efficacy profile then existing CNS therapies
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