Regional leader in preclinical R&D with a world-class directed evolution platform to create proteins/peptides to be utilized in cell and gene therapy (CGT) applications.
Using our unique platform, we are able to optimize natural peptides/proteins for cell and gene therapy (CGT) or other pharmaceutical applications. The natural peptides possess highly useful attributes (e.g. stability, solubility, low immunogenicity) and these features are maintained during the directed evolution. In contrast, other attributes, such as affinity towards the pharmacological target or off-target proteins are altered profoundly during the process.
WE APPLY THIS APPROACH IN TWO SUB-PLATFORMS:
MINIPROTEIN-BASED BIOPHARMACEUTICALS AND CELL AND GENE THERAPY We create peptide megalibraries with more than a million candidates from which promising leads can be selected and developed for specific targets. These peptides can be utilized in cell therapies such as CAR-T therapy or GMO enterobacteria.
SMALL MOLECULE CONTROLLED GENE THERAPY (CHEMOGENETICS) We are creating an engineered receptor – actuator pair, where the receptor has lost its ability to bind its endogenous ligand, has no constitutive activity, but activated by extreme low concentration of its actuator. To reach this goal, a megalibrary of cell-surface receptors or ion channels is generated and the members are screened for the advantageous characteristics. This technique may create a novel therapeutic class that can be utilized for the treatment of various debilitating CNS diseases.
We also run a drug repositioning (fixed-dose combinations, FDC) project in one of our partner laboratories to create new, safe and effective therapeutic options using drugs already on the market.
We deliver custom-made cell lines, develop and provide bioassays for your research and development. The exclusivity we provide ensures an increased competitive advantage over your competitors.
Our in house developed and in-licensed projects are managed applying a state of the art project management approach for discovery and pre-clinical development. We rely on the broad experience of our scientists in a wide range of in vitro and in vivo methodologies.
We are constantly looking for word class talent, join us if you want to work in an agile environment to stay ahead of the game in healthcare.